following directives to /etc/postfix/main.cf file:

=> disable_vrfy_command = yes : Disable the SMTP VRFY command. This stops some techniques used to harvest email addresses.

=> smtpd_delay_reject = yes : It allows Postfix to log recipient address information when rejecting a client name/address or sender address, so that it is possible to find out whose mail is being rejected.

=> smtpd_helo_requi
red = yes : Require that a remote SMTP client introduces itself at the beginning of an SMTP session with the HELO or EHLO command. Many spam bot ignores HELO/EHLO command and you save yourself from spam. Following lines further restrictions on HELO command:
smtpd_helo_restrictions = permit_mynetworks,
reject_non_fqdn_hostname, Reject email if remote hostname is not in fully-qualified domain form. Usually bots sending email don't have FQDN names.
reject_invalid_hostname, Reject all bots sending email from computers connected via DSL/ADSL computers. They don't have valid internet hostname.
permit

You can put the following access restrictions that the Postfix SMTP server applies in the context of the RCPT TO command.
=> smtpd_recipient_restrictions =
reject_invalid_hostname, - Reject email if it not valid hostname
reject_non_fqdn_hostname, - Reject email if it not valid FQDN
reject_non_fqdn_sender, - Reject the request when the MAIL FROM address is not in fully-qualified domain form. For example email send from xyz or abc is rejected.
reject_non_fqdn_recipient, - Reject the request when the RCPT TO address is not in fully-qualified domain form
reject_unknown_sender_domain, - Reject email, if sender domain does not exists
reject_unknown_recipient_domain, Reject email, if recipient domain does not exists
permit_mynetworks,
reject_rbl_client list.dsbl.org, Configure spam black lists
reject_rbl_client sbl.spamhaus.org,
reject_rbl_client cbl.abuseat.org,
reject_rbl_client dul.dnsbl.sorbs.net,
permit

Open /etc/postfix/main.cf file :
# vi /etc/postfix/main.cf
Set/modify configuration as follows

disable_vrfy_command = yes

smtpd_delay_reject = yes

smtpd_helo_required = yes

smtpd_helo_restrictions = permit_mynetworks,

     reject_non_fqdn_hostname,

     reject_invalid_hostname,

     permit

smtpd_recipient_restrictions =

   permit_sasl_authenticated,

   reject_invalid_hostname,

   reject_non_fqdn_hostname,

   reject_non_fqdn_sender,

   reject_non_fqdn_recipient,

   reject_unknown_sender_domain,

   reject_unknown_recipient_domain,

   permit_mynetworks,

   reject_rbl_client list.dsbl.org,

   reject_rbl_client sbl.spamhaus.org,

   reject_rbl_client cbl.abuseat.org,

   reject_rbl_client dul.dnsbl.sorbs.net,

   permit

smtpd_error_sleep_time = 1s

smtpd_soft_error_limit = 10

smtpd_hard_error_limit = 20

Also force (highlighted using red color) Postfix to limit incoming or receiving email rate to avoid spam.

Save and close the file. Restart postfix:
# /etc/init.d/postfix restart

Watch out maillog file. Now you should see lots of spam email blocked by above configuration directive:
# tail -f /var/log/maillog